Kill a Champion.

Gather 5 Artefacts during a game.

Make 3 heroes flee.

Apply 20 stacks of "Bleeding" to a single hero.

Kill 3 heroes simultaneously with a trap.

Upgrade a monster to max level.

Kill 3 heroes with a single attack.

Finish a game without seeing the Therapist.

Use only the same type of monsters during a dungeon.

Recruit 5 rare monsters with the Headhunter.

Steal 10 Artefacts from the Collector.

Summon 10 monsters in front of the Ninth Door.

Complete all missions with the Enchantress.

Complete all missions with the Slaveholder.

Complete all missions with the Engineer.

Complete level 5 of Ascension Mode with any Master.

Complete level 10 of Ascension Mode with any Master.

Complete level 15 of Ascension Mode with any Master.

Complete level 20 of Ascension Mode with any Master.

Reach 156 weeks in Endless Mode.

Reach 260 weeks in Endless Mode.

Unlock 25 Artefacts at the Archivist.

Unlock 35 Artefacts at the Archivist.

Unlock 45 Artefacts at the Archivist.