Minimalist Achievement in Resident Evil 3

If you haven't purchased the hip pouches in the Shop, I highly recommend you tackle this one on Standard difficulty. But if you have, it will expand your on-person inventory at the first safe room by four slots. Only pick up items that will propel the story forward and items you know you'll need. Make weapon pick ups a priority as the two handguns on Jill won't be necessary since they both use the same ammo type. Also, try not to run "I Might Need These Later!" with this run since you may get seriously hurt as the coins are located in the item box, especially when fighting Nemesis Stage 3. Save precious ammo by skipping fights by running by them. Hoard Lighting Hawk ammo as this weapon is beast later on against tougher enemies. Just combine high grade powder to make more ammo of it.

If you see an item you don't need, leave it. It will take up a necessary slot in your inventory that you'll just discard anyway. Combine ammo slots so that won't take up necessary slots, and load your weapons often.